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Antibacterial Activities of New (E) 2-Cyano-3-(3′,4′-dimethoxyphenyl)-2-propenoylamide Derivatives
Journal article   Peer reviewed

Antibacterial Activities of New (E) 2-Cyano-3-(3′,4′-dimethoxyphenyl)-2-propenoylamide Derivatives

A. K. El-Ziaty and S. A. Shiba
Synthetic communications, Vol.37(22), pp.4043-4057
01/11/2007
DOI: https://doi.org/10.1080/00397910701575491

Abstract

1,3,5-oxadiazine-2,4-dione benzimidazole benzoxazine
(E) 2-Cyano-3-(3′,4′-dimethoxyphenyl)-2-propenoyl chloride (2) underwent mono- and binucleophilic displacement with hydrazines, amines, ureas, and aromatic bifunction amines to give new 2-propenoyl hydrazines (4 and 5), 2-propenoylamide (6, 7, 12, 13, 15, 17, 19, 21), and 2-thiol propenoate (22-24). Some of these products were cyclized to give novel heterocyclic derivatives (8, 10, 14, 16, and 20).

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