Abstract
To synthesize and characterize novel 3-chloro-2-oxo-N-phenyl-4-arylazetidine-1-carboxamide derivatives (3a-3g) and evaluated them for in vitro antibacterial activity. Compounds 3a-3g were synthesized by reacting various 1-arylidene-3-phenylurea derivatives (Schiff bases, 2a-2g), with chloroacetyl chloride in the presence of dimethylformamide, triethylamine, and 1,4-dioxane. Schiff bases 2a-2g were synthesized by the reaction of phenyl urea (1) with appropriate aromatic aldehydes. Compound 1 was synthesized by the reaction of aniline with urea in presence of glacial acetic acid and concentrated hydrochloric acid. The synthesized compounds 3a-3g were established by infrared (IR), proton nuclear magnetic (1HNMR), and mass spectral analysis. Compounds 3g with 4-dimethyl amino- phenyl group was exhibited good antimicrobial activity against Gram-positive bacteria and compound 3d with 4-methyl phenyl group was exhibited good antimicrobial activity against Gram-negative bacteria. Ciprofloxacin was used as a standards drug.