Abstract
In the current investigation the traditional aqueous and ethanolic extraction products from leaves of Sphaeranthus indicus and flowers of Helianthurs annul were evaluated for antibacterial activity against multi drug resistant (MDR) bacterial isolates from the clinical samples. Standard tube dilution and disc diffusion methods were employed to assess the antibacterial activity. The results showed, ethanolic sphaeranthus extract at a minimum inhibitory concentration (MIC) of 3mg/ml by tube dilution & 1.8 mg/ml by disc diffusion method inhibited the growth of MDR Staphylococcus and Klebsiella. Further the MDR E.coli and psendomonas were effectively inhibited by the ethanolic extract of Hellanthus at a concentration of 4 mg/ml and 2.5 mg/ml. by tube dilution and disc diffusion methods respectively The aqueous extracts of both the herbs showed a transient antibacterial activity against MDR staphylococcus isolate, while there was no observable activity against MDR E.coli, pseudomonas or klebsiella isolates. Collectively targeting the MDR isolates may pave a way for future class of drugs from natural products in way they have been extracted and used for generations (C) 2016 IASE Publisher. All rights reserved.