Abstract
Swietenia mahagoni Jacq. (Meliaceae) seeds and bark were used traditionally for the treatment of hypertension, diabetes, malaria, and in epilepsy. In the present study the phytochemical investigations involve the extraction of plant material obtained by following cold maceration with ethanol and the percentage yield of the extract is 12.86% and identification of the phytoconstituents. Then the solvent extraction process was processed by the following order of polarity as petroleum ether, benzene, ethyl acetate and ethanol. These extractions were evaluated for anti microbial activity by Cup Plate method, a commercial sample ofloxacin is used as standard antibiotic. Sterile Petri dishes were filled to a depth of 4.5 mm with sterile nutrient agar medium that had previously been inoculated with a suitable inoculum of test organism of P. aeruginosa-MCC2080, B. licheniformis-MCC2297, P. mirabilis-,S. aureus-MCC2408 and E.Coli-MCC2246 individually at 45 degrees C to 50 degrees C. 0.1ml of the standard drug and test extract were poured into bored wells by means of 1ml sterile syringe and incubated at 37 degrees c for 24 hours. The ethanolic extract and ethyl acetate extract of S. mahagoni Jacq. seed at different dose (40,60,80mg/ml) level showing significant antimicrobial activity. The plant can be considered as low cost, potent, herbal medicine for good anti-microbial activity.