Abstract
Although tris(8-hydroxyquinoline)aluminum (Alq(3)), a fluorescent optical organometallic material, is known for its applications in optoelectronics, it has only few and limited applications in the biological field. In this study, the antibacterial activity of Alq(3) micro and nanostructures was investigated. We prepared Alq(3) nanostructures. We prepared nanosized Alq(3) as rice-like structures that assembled into flower shapes with an alpha-crystal phase. Then, Alq(3) micro and nanostructure antibacterial activities were estimated against seven human pathogenic bacterial strains. Besides, we compared their antibacterial activities with those of standard antibiotics. The minimal inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and IC50 were evaluated. Alq(3) micro and nanostructure antibacterial activity showed considerable values compared to standard antibiotics. Besides, the obtained data revealed that the antibacterial activity of Alq(3) in nanostructures with a new morphology is more than that in microstructures. The antibacterial activity of Alq(3) nanostructures was attributed to their more surface interactions with the bacterial cell wall. The molecules of 8-hydroxyquinoline in the Alq(3) structure could play crucial roles in its antibacterial activity. To apply the achieved results, Alq(3) was incorporated with polystyrene (PS) in a ratio of 2% to fabricate a PS/Alq(3) composite and used to coat glass beakers, which showed inhibition in the bacterial growth reduced to 65% compared with non-coated beakers. The finding of this study showed that Alq(3) could be used as a promising antimicrobial coating.