Abstract
Two new sesquiterpenoids belonging to the guaiane, 4 alpha,9 alpha,10 alpha-trihydroxyguaia-11(13)en-12,6 alpha-olide (1), and germacrane, 9 beta-hydroxyparthenolide-9-O-beta-D-glucopyranoside (2), classes have been isolated from the leaves of the Saudi medicinal plant Anvillea garcinii along with seven known compounds (3-9). The structures of the new metabolites were elucidated by spectroscopic analysis, including one-dimensional (1D) and two-dimensional (2D) Nuclear Magnetic Resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HR-ESIMS). The antimicrobial properties of 1-9 were screened against seven different pathogenic microbes, and compounds 1-3 showed a potent antifungal activity.