Abstract
A new series of eight compounds 1-(4'-O-beta-d-glucopyranosyloxy-2'-hydroxy-5'-substituted phenyl)-3-heteroaryl-propane-1,3-diones (DKG) were prepared by the interaction of alpha-acetobromoglucose with 1-(2',4'-dihydroxy-5'-substituted phenyl)-3-heteroaryl-propane-1,3-diones under anhydrous condition at lower temperature. The structures of these O-beta-d-glucopyranosides were established on the basis of chemical, elemental, and spectral analyses. Further, the compounds were tested for their antibacterial, antifungal, and antioxidant properties. A correlation of structure and activities relationship of these compounds with respect to molecular modeling, Lipinski rule of five, drug-likeness, toxicity profiles, and other physico-chemical properties of drugs are described and verified experimentally.