Abstract
A series of new compounds carrying 1,3-thiazole and 2-thiohydantoin scaffold were synthesized and structurally confirmed by different spectroscopic methods such as IR, H-1-NMR, C-13-NMR and mass spectroscopy along with elemental analyses. All the synthesized compounds were examined for their cytotoxic activity versus HepG2 cell line. Compound 4 and its acetylated derivative showed the least IC50 values within the tested compounds. Additionally, compounds 4 and 6 were evaluated against VEGFR-2. The results revealed that compound 4 showed good VEGFR-2 inhibitory activity. Moreover, cell cycle analysis of compound 4 appeared cell cycle arrest at both G1 and G2/M phase of cell cycle profile of HepG2 cells.