Abstract
N-(Benzo[d] [1,3] dioxol-5-ylmethyl)-2-cyanoacetamide 2 was utilized as a key intermediate for the synthesis of acrylamides 3-8, 1,2-dihydropyridines 9-16 and 25, dihydroquinoline 18 2,3-dihydrothiazoles 19-24, chromenes 26,27, and benzochromenes 28,29. The structure of the newly synthesized compounds was confirmed on the basis of elemental analyses and spectral data. All the newly synthesized compounds were evaluated for their cytotoxic activity against breast cancer cell line MCF7. Compound 22 exhibited higher activity with IC50 value (3.68 mu g/mL) compared to doxorubicin with IC50 value (5.75 mu g/mL) as reference drug. Also, compounds 23, 17, 21, 19, 24, 16 and 9 are nearly as active as doxorubicin, while compounds 2, 4, 5, 6, 10, 15, 18, 25, 26 and 28 exhibited a moderate activity. In addition compounds 3, 13 and 20 showed less activity than doxorubicin, while compounds 7, 11, 12, 14, 27 and 29 showed no activity.