Abstract
Seventeen novel compounds of sulfonamides incorporating biologically active heterocyclic with thiourea moieties (3-11, 18, 19) and quinazoline derivatives carrying a sulfonamide moieties (12-17) were designed and synthesized utilizing of 4-isothiocyanatobenzenesulfonamide 2 as strategic starting material. Newly prepared compounds were evaluated for their anticancer activity against various cancer cell lines. Compound 9 exhibited higher activity against breast cancer cell line MDA-231 compared with the reference drug 2', 7', dichlorofluorescein (DCF). Likewise, compound 9 revealed a remarkable activity against cervical cell line (Hela). In contrast, the quinazoline derivative 16 showed more potent against colorectal (Lovo) and breast cancer (MDA-231) cell lines compared with the positive control DCF. Furthermore compound 16 exhibited a remarkable activity against cervical cancer cell line (Hela). Compounds 2-8, 10-15 and 17-19 showed no activity.