Abstract
•Anticancer activity of Tio2/Gold nanocomposite prepared by laser ablation technique.•Cytotoxicity in breast and cervical cancers.•Cervical (HELA) and breast (MCF7) cancer cell lines using MTT (3-(4, 5-Dimethylthiazol-2-yl)-2, 5-Diphenyltetrazolium Bromide) method.•TiO2-Au nanocomposite could potentially used to inhibit the growth of cancerous cells.
This work reports the synthesis of TiO2 nanowires (NWs) decorated with Au nanoparticles (NPs) by pulsed laser ablation technique for anticancer applications. Various analytical techniques were employed to characterize the fabricated samples including field emission scanning electron microscopy (FESEM), energy dispersive X-ray spectrometry (EDX), UV–Vis spectrophotometry, Raman spectroscopy, and photoluminescence (PL). The FESEM images confirm the anchoring of Au NPs on the surfaces of the TiO2 NWs. The anticancer activity of pristine TiO2 NWs, Au NPs, and TiO2-Au nanocomposite were evaluated on cervical (HELA) and breast (MCF7) cancer cell lines using MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) method. The results show that the decoration of TiO2 NWS with Au NPs significantly enhanced the anticancer activities against MCF7 and HELA cancer cells with an improvement of 43% and 41 %, respectively. Thus, TiO2-Au nanocomposite prepared using pulsed laser ablation could potentially be used to inhibit the growth of cancerous cells.