Abstract
Eighteen new 4-[2-amino-3-cyano-5-oxo-4-substitutedaryl-4
H
-indeno[1,2-b]pyridin-1-(
5H
)-yl]benzenesulfonamide derivatives
6a–q
were synthesized via a reaction of aromatic aldehydes, enaminone
3
and malononitrile in one-pot reaction. Also, compounds
6a–q
were obtained, via another route by reaction of enaminone
3
with arylidenemalononitriles
4a–q
. The structure of the synthesized compounds was characterized by microanalysis, IR,
1
H-NMR,
13
C-NMR and mass spectral data. All the target compounds were subjected to
in vitro
anticancer activity against breast cancer cell line (MCF7). Compound
6d
showed a higher potency with IC
50
value (4.34 μM) than that of the Doxorubicin (5.40 μM), as the reference drug, while compound
6n
with IC
50
value (6.84 μM) is nearly as active as Doxorubicin. Also, compounds
6a–c, 6e, 6f, 6h
and
6p
exhibited a moderate activity, while compounds
3, 6g, 6i–m, 6o
and
6q
showed weak activity.