Abstract
A series of thiazole derivatives were synthesized and structurally elucidated by IR,
H NMR,
C NMR, mass and elemental analyses. The prepared compounds were screened for their cytotoxic activity against Leukemia HL-60 cell line. Compound
was considered as the most promising antitumor candidate among the tested compounds. Mechanism of action of compound
evaluated by flow cytometric assay revealed cell cycle arrest at G2/M phase and pre-G1 apoptosis. The ratio of apoptosis was also determined. Moreover, compound
increased the concentration of caspase 3 by 4 fold more than untreated control.