Abstract
A novel series of quinazolines incorporating a biologically active 4, 6-dimethylpyrimidine, 1, 2, 4-triazine, benzo[d][1,3]dioxol, morpholinophenyl, quinoline, sulfonamide and thioureamoieties9-14, 15,16,19, 20 and 2-hydrazinylquinazoline derivative 22were designed and synthesized using methyl 2-isothiocyanato derivative2 as strategic starting material. The structure of the newlysynthesized compounds was confirmed by elemental analyses and spectral data. All the prepared compounds were evaluated for their invitro anticancer activity against breast cancer cell lines. It was found that quinazoline carrying free amino group at 3-position with sulfa-phenazolegroup at 2-position20 and thioureido derivative bearing sulfa-phenazolel6 with IC(50)values (2.64 and 4.60 mu g/mL) showed better activity thandoxorubicin as positive control. In addition compounds 14, 12 and 15 are nearly as active as doxorubicin as reference drug, while compounds 9, 13, 11 and 19 exhibited a moderate activity. On the other hand, compounds 10 and 22 showed no activity.