Abstract
A new series of 5-arylhydrazonothiazole derivatives
5a–d
has been synthesized, elucidated, and evaluated for their antidermatophytic activity. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of the newly synthesized products were investigated against 18 dermatophyte fungal isolates related to
Epidermophyton floccosum
,
Microsporum canis
, and
Trichophyton rubrum
. The morphological alterations induced by the synthesized derivatives singly or conjugated with the monoclonal antibody were examined on spores of
T. rubrum
using a scanning electron microscope. The efficacy of synthesized derivative
5a
applied at its respective MFC alone or conjugated with anti-dermatophyte monoclonal antibody 0014 in skin infection treatment of guinea pigs due to inoculation with one of the examined dermatophytes, in comparison with fluconazole as standard reference drug was evaluated. In an in vivo experiment, the efficiency of
5a
derivative conjugated with the antibody induced 100% healing after 45 days in the case of
T. rubrum
and
M. canis
-infected guinea pigs.