Abstract
Two new flavonol methyl ether: caryatin-3′ sulfate (
6) and caryatin-3′ methyl ether-7-
O-β-D-glucoside (
7) were isolated from
Carya illinoinensis bark together with five known metabolites. The isolated compounds were investigated for their hypoglycaemic, antioxidant as well as the aldose reductase (AR) inhibitory effect in lenses of streptozotocin diabetic rats.
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► Seven phenolic compounds were characterized from bark of Pecan tree; two of them are new and the others are known. ► Hypoglycemic, antioxidant and aldose reductase inhibitory effect in lenses of diabetic rats were evaluated for the compounds. ► Compound
3 and its glucoside
7 revealed the highest hypoglycaemic and AR-inhibitory effects.
The
n-butanol fraction (BF) of bark of Pecan tree,
Carya illinoinensis (Wangenh) K. Koch (Juglandaceae) afforded two new flavonol methyl ether: caryatin-3′ sulfate (
6) and caryatin-3′ methyl ether-7-
O-β-
d-glucoside (
7) while five known phenolics (
1–
5) were isolated from its ethyl acetate fraction (EAF). The structures of isolated compounds were established based on 1D and 2D NMR spectroscopy. The isolated compounds were investigated for their hypoglycaemic, antioxidant as well as the aldose reductase (AR) inhibitory effect in lenses of streptozocin diabetic rats. All the isolated compounds showed significant hypoglycaemic and antioxidant activities, except
5 and
6. A marked AR-inhibitory effect was identified for compounds
2,
3 and
7.