Abstract
Gold nanoparticles (7 and 15nm) of very high surface area (329 and 269m2/g) have been successfully synthesized through solvothermal method by using tin chloride and sodium borohydride as reducing agents. As-prepared gold nanoparticles shows very excellent antifungal activity against Candida isolates and activity increases with decrease in the particle size. [Display omitted]
► Effect of reducing agents on the morphology of gold nanoparticles. ► Highly uniform and monodisperse gold nanoparticles (7nm). ► Highest surface area of gold nanoparticles (329m2/g). ► Excellent antifungal activity of gold nanoparticles against Candida strains.
Gold nanoparticles have been successfully synthesized by solvothermal method using SnCl2 and NaBH4 as reducing agents. X-ray diffraction studies show highly crystalline and monophasic nature of the gold nanoparticles with face centred cubic structure. The transmission electron microscopic studies show the formation of nearly spherical gold nanoparticles of average size of 15nm using SnCl2, however, NaBH4 produced highly uniform, monodispersed and spherical gold nanoparticles of average grain size of 7nm. A high surface area of 329m2/g for 7nm and 269m2/g for 15nm gold nanoparticles was observed. UV–vis studies assert the excitations over the visible region due to transverse and longitudinal surface plasmon modes. The gold nanoparticles exhibit excellent size dependant antifungal activity and greater biocidal action against Candida isolates for 7nm sized gold nanoparticles restricting the transmembrane H+ efflux of the Candida species than 15nm sized gold nanoparticles.