Abstract
A series of N-(3-chloro-2-aryl-4-oxoazetidin- 1-yl)-4-nitro benzamide derivatives (4a-g) were synthesized by reacting various N'-arylidene-4-nitro benzo hydrazide (3a-g) with chloro acetyl chloride in the presence of triethylamine and dioxane. Infrared (IR), proton nuclear magnetic resonance ((HNMR)-H-1), and mass (MS) spectrometric techniques were used to describe the structure of synthesized compounds, which were further tested for in vitro antibacterial activity, and benzylpenicillin was used as a reference drug. Compounds (4b) and (4e) were showed high antibacterial action, whereas the remaining compounds (4a, 4c, 4d, 4f, and 4g) were showed moderate activity. Finally, this research demonstrates the design and development of novel antibacterial agents.