Abstract
In this work, Schiff's bases (1a-1d) were cyclized with heterocyclic aromatic aldehydes in presences of chloro acetyl chloride, triethylamine, and 1,4-dioxane to produce a series of 3-chloro-2-oxo-azetidine-1-yl)nicotinamide derivatives (2a-2d). Spectral analyses, such as IR,H-1 NMR,(CNMR)-C-13, and mass spectral data, were used to characterize the structures of the synthesized derivatives. Antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Gram-positive bacteria, and Escherichia coli, Pseudomonas aeruginosa, Gram-negative bacteria as well as antifungal activity against Candida albicans was also tested. These synthesized compounds were shown to be effective against tested bacterial as well fungal strains.