Abstract
.
has been implicated in infections of treated root canals. Current irrigants and intracanal medicaments cannot eliminate
completely from the root canal. Silver diamine fluoride (SDF) prevents caries by promoting remineralization and exerting an antibacterial effect. Studies suggest that SDF may possess antibacterial properties against
. The purpose of this review is to systematically and critically analyze the literature, focusing on the use of SDF as an intracanal medicament or irrigant, when compared to other antibacterial agents.
. The focused question was "Is the antibacterial effect of SDF against
better than other intracanal medicaments and irrigants?" Using the keywords ((silver diamine fluoride) AND (
)) AND ((sodium hypochlorite) OR (NaOCl) OR (chlorhexidine) OR (calcium hydroxide) OR (Ca(OH)
)), an electronic search was conducted on the following databases: PubMed/MEDLINE, ISI Web of Science, Scopus, EMBASE, and Google Scholar. The clinical trial registers ClinicalTrials.gov and CONTROL were also searched using the same keywords. General characteristics and outcomes were extracted, and quality of the studies was assessed using the Preferred Reporting Items for Laboratory studies in Endodontology (PRILE) guidelines.
. Six articles (five
studies and one
study) were included in this systematic review. In the majority of the studies, SDF had equal or better antibacterial efficacy against
compared to calcium hydroxide, sodium hypochlorite, and chlorhexidine. However, the majority of the studies did not fulfill several items in the PRILE criteria and had numerous sources of bias.
. Within the limitations of the systematic review and the studies reviewed, SDF may be effective against
and therefore could be used as an intracanal medicament and/or irrigant to prevent reinfections of the root canals and improve the outcomes of endodontic treatment. However, animal and clinical studies should be carried out to determine the efficacy of SDF in endodontics.
. The protocol for this review was registered on PROSPERO. Registration number: CRD42021224741.