Abstract
Antimicrobial activities of the methanolic extract from Lippia nodiflora and isolated compound from the extract were studied by the disc diffusion method. 100 mu g/ml of methanolic extract of Lippia nodiflora was recorded the minimun inhibitory concentration as compared with standard drug kanamycin and clotrimazole ( 10 mu g). The extracts showed antimicrobial impact on both gram positive and negative bacteria such as E. coli, P. vulgaris, K. pneumonia, B. cereus, B. subtilis, S. aureus, P. aeruginosa and B. clausii as well as fungi such as A. niger and C. albicans. The results showed that increasing concentrations of extracts increased the antimicrobial activities against all of the microorganisms. Bacteria were more sensitive than fungi, and gram positive bacteria were more sensitive to L. nodiflora extract than gram negative ones. It has been concluded that methanolic extract of Lippia nodiflora possess potential antimicrobial activity.