Abstract
Klebsiella pneumoniae
is an important human pathogen in both developing and industrialised countries that can causes a variety of human infections, such as pneumonia, urinary tract infections and bacteremia. Like many Gram-negative bacteria, it is becoming resistant to many frontline antibiotics, such as carbapenem and cephalosporin antibiotics. In Egypt,
K. pneumoniae
is increasingly recognised as an emerging pathogen, with high levels of antibiotic resistance. However, few Egyptian
K. pneumoniae
strains have been sequenced and characterised. Hence, here, we present the genome sequence of a multidrug resistant
K. pneumoniae
strain, KPE16, which was isolated from a child in Assiut, Egypt. We report that it carries multiple antimicrobial resistance genes, including a
bla
NDM-1
carbapenemase and extended spectrum β-lactamase genes (i.e.,
bla
SHV-40
,
bla
TEM-1B
,
bla
OXA-9
and
bla
CTX-M-15
). By comparing this strain with other Egyptian isolates, we identified common plasmids, resistance genes and virulence determinants. Our analysis suggests that some of the resistance plasmids that we have identified are circulating in
K. pneumoniae
strains in Egypt, and are likely a source of antibiotic resistance throughout the world.