Abstract
In this study, we investigated the sea cucumber Holothuria tubulosa as a source of novel antimicrobial compounds. Three extracts isolated from the coelomic fluid (El) and body wall (E2 and E3) using different solvents were tested for their antimicrobial activities. Inhibition activity of extracts was assessed against bacterial and fungal species pre-clustered in two collections of pathogens depending on their starting biomasses (A and B collections). The highest growth inhibitory effect was found in the body wall extracts, followed by the coelomic fluid extract. In both sets of pathogens, significant sensitivities were obtained, but the most potent antibacterial extracts were the ethanol extracts. The results of this study highlight the antimicrobial activities of H. tubulosa and confirmed the health-promoting effects that are described in traditional medicine.