Abstract
The aim of present finding was to explore the extracts of Skimmia laureola barks and leaves for various pharmacological activities. The extract showed strong susceptibility against Micrococcus leutus, Escherichia coli, Pasteurella multocida, Bacillus subtilis and Streptococcus viridans with MIC in range 010.65-125 mg/ml, 0.67-5 mg/ml, 0.65-125 mg/ml, 1.25-5 mg/ml, and 2.5-5 mg/ml, respectively. In antifungal assay, ethanol and n-hexane extracts of leaves exhibited 70.97% and 64.52% against Aspergillus flavus in a concentration dependent manner, respectively. The ethanol and n-hexane extracts of barks elicited concentration dependent cytotoxicity with 11:150 of 180 and 115 while ethanol and n-hexane extracts of leaves demonstrated 5.34 mu g/ml and 7.44 mu g/ml. Similarly, the ethanol and n-hexane extracts of barks evoked concentration dependent phytotoxicity with LD50 of 25 mu g/ml and 1.38 mu g/ml, respectively, while the ethanol and n-hexane extracts of leaves had LD50 of 4.54 and 8.67 mu g/ml, respectively. In conclusion, the ethanol and n-hexane extracts of both barks and leaves of the plant showed marked antibacterial activity against a variety of bacteria which was strongly supported by their cytotoxic and phytotoxic effects.