Abstract
Purification of the organic extract of
Lamouroux by column chromatography and preparative thin layer chromatography provided four new compounds: a eudesmane-type sesquiterpenoid [eudesma-4(15),11-diene-5,7-diol (
)], a cuparane-type sesquiterpenoid [10-hydroxycuparaldehyde (
)], and two
-cuparanes [3-hydroxy-15-
-cuparan-10β-ol (
) and 2-bromo-3-hydroxy-15-
-cuparan-10β-ol (
)]. Structural identification was made possible by comparison of spectral data with those reported in the literature. Compounds
and
are significant as
-cuparanes are rarely isolated from marine environment.
showed moderate anticandidal activity, whereas
exhibited reasonable antibacterial activity against multidrug-resistant bacteria (especially Gram-positive). All the compounds are nontoxic to