Abstract
Thiazolidinone derivatives represent heterocyclic bioactive compounds. We have synthesized some N-(5-methyl-4-oxo-2-arylthiazolidin-3-yl)-isonicotinamide derivatives (
2a–2h
) from isoniazid (INH) and screened them as antimycobacterial agents against
M. tuberculosis
H37Rv strain using microplate alamar blue assay (MABA). Compounds
2a-2h
were obtained via cyclocondensation of N-arylideneisonicotinohydrazide derivatives (imine Schiff’s bases)
1a-1h
with thiolactic acid. Initial compounds
1a-1h
were synthesized by reaction of isoniazid with appropriate benzaldehyde. The structures of title compounds were established by IR, 1H NMR, and mass spectroscopy data. All the title compounds (
2a-2h
) exhibited antimycobacterial activity and were compared to standard drugs streptomycin (MIC value of 6.25 μg/mL) and isoniazid (MIC value of 3.125 μg/mL). Compound
2g
exhibited the highest antimycobacterial activity, but all the tested compounds were less active than standard drugs.