Abstract
The continuous demand for new chemotherapeutic agents indicates that new approaches are critically needed. The current study was under taken to examine the effect of the two novel antitumor complexes namely cobalt and chromium complexes of bis-(4-bromobenzaldehydeiminoacetophenone), BBIA-Co and BBIA-Cr, on liver, kidney and heart of Ehrlich ascites carcinoma (EAC) bearing male albino mice. The effect of the two complexes on antioxidant status of the animals and histopathological examination of liver, kidney and heart tissues were also examined. Results indicated that treatment with either BBIA-Co or BBIA-Cr had ameliorated to some extent the changes in liver function exerted by EAC inoculation. Both complexes had no significant effect on kidney function, while they induced cardiac toxicity to animals. The study also showed no significant changes in the antioxidant status of EAC inoculated mice treated with BBIA-Co compared to normal animals, which was not indicated after BBIA-Cr treatment. The biochemical data results were further supported by histopathological examination.