Abstract
Antioxidant activity of the aqueous (AET) and methanolic extracts (MET) of the
Thespesia populnea bark was investigated in rats by inducing liver injury with carbon tetrachloride:olive oil (1:1). The extracts exhibited significant antioxidant activity showing increased levels of glutathione peroxidase (GPX), glutathione S-transferase (GST), glutathione reductase (GRD), superoxide dismutase (SOD) and catalase (CAT) and decreased level of lipid peroxidation (LPO).
Thespesia populnea bark extracts, AET and MET, at a dose level of 500
mg/kg showed significant antioxidant activity against carbon tetrachloride-induced liver injury in rats.