Abstract
The current study aimed to investigate the antioxidant, anti-inflammatory and hepatoprotective activity of olive fruit pulp extract (OFPE) through in vivo- and in vitro-based studies. Oral administration of OFPE demonstrated a significant reduction in liver biomarker enzymes, inflammatory marker (IL-6, TNF-α, and C-reactive protein (CRP)) level and recovered the antioxidant enzymes and total antioxidant capacity levels when compared to CCl
4
treated group. The histopathological alterations were seen in CCl
4
treated mice. The hepatocyte architecture was maintained in OFPE treated group as compared to the CCl
4
treated group. The anti-inflammatory activity of the OFPE was evaluated through in vitro and was found to be similar with a reference drug, ibuprofen. Current findings revealed that OFPE displays hepatoprotective effect through enhancement of antioxidant enzyme level, reduction of anti-inflammatory and maintenance of hepatocyte architecture. Thus, olive fruit extract might be utilized as a therapeutic alternative in the treatment of hepatic complications.