Abstract
A series of fourteen pyrimido[1,2-
]benzimidazole compounds was prepared by straightforward heterocyclic chemistry and oxidation methods. The new pyrimidobenzimidazole derivative
with a 3-fluorophenyl substituent was identified as a new antiparasitic compound showing excellent activities against
parasites.
was highly active against
promastigotes and amastigotes with EC
values in the nanomolar concentration range. Compound
was less active than
against
, but more active against
with considerable selectivity. Hence, two promising and selective antiparasitic drug candidates
and
for the treatment of two parasitic diseases were identified, which can be prepared by green chemistry methods using simple one-pot reactions and oxidation procedures, respectively.