Abstract
The ATP-binding cassette (ABC) transporters have an important role in disposition of many drugs. Antipsychotics (Aps) are known to be substrates and potential inhibitor for these transporters with unclear underlying mechanisms. This study investigated the effects of APs: chlorpromazine (CPZ), risperidone (RIS), clozapine (CLZ), haloperidol (HAL) on the functions of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) transporters in Wistar albino rats' isolated micro-vascular endothelial cells (RMVECs) of blood brain barrier (BBB) using wide range of therapeutic and toxic concentrations. APs was shown to inhibit the function of both transporters in a concentration dependant manner especially RIS with significant decrease in their ATP synthesis, ATP hydrolase activities and expression of the transporters proteins in a concentration dependant manner. This can be a potential source for drugs interaction at the level of these transporters.