Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices

Sajal Gupta; Rakesh Sharma; Ashok Agarwal; Florence Boitrelle; Renata Finelli; Ala'a Farkouh; Ramadan Saleh; Taha Abo-Almagd Abdel-Meguid; Murat Gül; Birute Zilaitiene; Edmund Ko; Amarnath Rambhatla; Armand Zini; Kristian Leisegang; Shinnosuke Kuroda; Ralf Henkel; Rossella Cannarella; Ayad Palani; Chak-Lam Cho; Christopher C K Ho; Daniel Suslik Zylbersztejn; Edoardo Pescatori; Eric Chung; Fotios Dimitriadis; Germar-Michael Pinggera; Gian Maria Busetto; Giancarlo Balercia; Gianmaria Salvio; Giovanni M Colpi; Gökhan Çeker; Hisanori Taniguchi; Hussein Kandil; Hyun Jun Park; Israel Maldonado Rosas; Jean de la Rosette; Joao Paulo Greco Cardoso; Jonathan Ramsay; Juan Alvarez; Juan Manuel Corral Molina; Kareim Khalafalla; Kasonde Bowa; Kelton Tremellen; Evangelini Evgeni; Lucia Rocco; Marcelo Gabriel Rodriguez Peña; Marjan Sabbaghian; Marlon Martinez; Mohamed Arafa; Mohamed S Al-Marhoon; Nicholas Tadros; Nicolas Garrido; Osvaldo Rajmil; Pallav Sengupta; Paraskevi Vogiatzi; Parviz Kavoussi; Ponco Birowo; Raghavender Kosgi; Saleem Bani-Hani; Sava Micic; Sijo Parekattil; Sunil Jindal; Tan V Le; Taymour Mostafa; Tuncay Toprak; Yoshiharu Morimoto; Vineet Malhotra; Azin Aghamajidi; Damayanthi Durairajanayagam; Rupin Shah

doi:10.5534/wjmh.210164

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Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices

Journal article

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Peer reviewed

Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices

Sajal Gupta, Rakesh Sharma, Ashok Agarwal, Florence Boitrelle, Renata Finelli, Ala'a Farkouh, Ramadan Saleh, Taha Abo-Almagd Abdel-Meguid, Murat Gül, Birute Zilaitiene, …

The world journal of men's health, Vol.40(3), pp.380-398

01/07/2022

DOI: https://doi.org/10.5534/wjmh.210164

PMID: 35021297

Abstract

Antibodies

Spermatozoa

Survey

Infertility, male

Sperm agglutination

Antisperm antibodies (ASA), as a cause of male infertility, have been detected in infertile males as early as 1954. Multiple causes of ASA production have been identified, and they are due to an abnormal exposure of mature germ cells to the immune system. ASA testing (with mixed anti-globulin reaction, and immunobead binding test) was described in the WHO manual 5th edition and is most recently listed among the extended semen tests in the WHO manual 6th edition. The relationship between ASA and infertility is somewhat complex. The presence of sperm agglutination, while insufficient to diagnose immunological infertility, may indicate the presence of ASA. However, ASA can also be present in the absence of any sperm agglutination. The andrological management of ASA depends on the etiology and individual practices of clinicians. In this article, we provide a comprehensive review of the causes of ASA production, its role in immunological male infertility, clinical indications of ASA testing, and the available therapeutic options. We also provide the details of laboratory procedures for assessment of ASA together with important measures for quality control. Additionally, laboratory and clinical scenarios are presented to guide the reader in the management of ASA and immunological male infertility. Furthermore, we report the results of a recent worldwide survey, conducted to gather information about clinical practices in the management of immunological male infertility.

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Title: Antisperm Antibody Testing: A Comprehensive Review of Its Role in the Management of Immunological Male Infertility and Results of a Global Survey of Clinical Practices
Creators - without role: Sajal Gupta - Cleveland Clinic
Rakesh Sharma - Cleveland Clinic
Ashok Agarwal - Cleveland Clinic
Florence Boitrelle - Centre Hospitalier Intercommunal de Poissy
Renata Finelli - Cleveland Clinic
Ala'a Farkouh - Cleveland Clinic
Ramadan Saleh - Sohag University
Taha Abo-Almagd Abdel-Meguid - Minia University
Murat Gül - Selçuk University
Birute Zilaitiene - Lithuanian University of Health Sciences
Edmund Ko - Loma Linda University
Amarnath Rambhatla - Henry Ford Health System
Armand Zini - McGill University
Kristian Leisegang - University of the Western Cape
Shinnosuke Kuroda - Cleveland Clinic
Ralf Henkel - Cleveland Clinic
Rossella Cannarella - University of Catania
Ayad Palani - Kurdistan Regional Government
Chak-Lam Cho - Chinese University of Hong Kong
Christopher C K Ho - Taylor's University
Daniel Suslik Zylbersztejn - Hospital Israelita Albert Einstein
Edoardo Pescatori - GynePro Medical
Eric Chung - Princess Alexandra Hospital
Fotios Dimitriadis - Aristotle University of Thessaloniki
Germar-Michael Pinggera - Innsbruck Medical University
Gian Maria Busetto - Ospedali Riuniti di Foggia
Giancarlo Balercia - Marche Polytechnic University
Gianmaria Salvio - Marche Polytechnic University
Giovanni M Colpi - Andrology Unit, Procrea Institute, Lugano, Switzerland, Turkey
Gökhan Çeker - Samsun University
Hisanori Taniguchi - Kansai Medical University
Hussein Kandil - IVI Middle East Fertility Clinic
Hyun Jun Park - Pusan National University Hospital
Israel Maldonado Rosas - Citmer Reproductive Medicine, IVF LAB, Mexico City, Mexico, Turkey
Jean de la Rosette - Department of Urology, Istanbul Medipol Mega University Hospital, Istanbul, Turkey
Joao Paulo Greco Cardoso - Universidade de São Paulo
Jonathan Ramsay - Hammersmith Hospital
Juan Alvarez - Harvard University
Juan Manuel Corral Molina - Servicio de Urología, Hospital Clínico de Barcelona. Barcelona, Spain
Kareim Khalafalla - Hamad Medical Corporation
Kasonde Bowa - University of Lusaka
Kelton Tremellen - Flinders University
Evangelini Evgeni - Cryogonia Cryopreservation Bank, Athens, Greece, Italy
Lucia Rocco - University of Campania "Luigi Vanvitelli"
Marcelo Gabriel Rodriguez Peña - Hospital Militar Central
Marjan Sabbaghian - Royan Institute
Marlon Martinez - University of Santo Tomas Hospital
Mohamed Arafa - Cleveland Clinic
Mohamed S Al-Marhoon - Sultan Qaboos University
Nicholas Tadros - Southern Illinois University School of Medicine
Nicolas Garrido - Instituto de Investigación Sanitaria La Fe
Osvaldo Rajmil - Puigvert Foundation
Pallav Sengupta - Mahsa University
Paraskevi Vogiatzi - Andromed
Parviz Kavoussi - The University of Texas Health Science Center at San Antonio
Ponco Birowo - Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo
Raghavender Kosgi - Asian Institute of Gastroenterology
Saleem Bani-Hani - Jordan University of Science and Technology
Sava Micic - Department of Andrology, Uromedica Polyclinic, Belgrade, Serbia
Sijo Parekattil - University of Central Florida
Sunil Jindal - Department of Andrology and Reproductive Medicine, Jindal Hospital, Meerut, India
Tan V Le - Department of Andrology, Binh Dan Hospital, Ho Chi Minh City, Viet Nam, Egypt
Taymour Mostafa - Cairo University
Tuncay Toprak - Fatih Sultan Mehmet Eğitim Ve Araştırma Hastanesi
Yoshiharu Morimoto - Osaka Nishi Clinic
Vineet Malhotra - Department of Andrology and Urology, Diyos Hospital, New Delhi, India
Azin Aghamajidi - Iran University of Medical Sciences
Damayanthi Durairajanayagam - Universiti Teknologi MARA
Rupin Shah - Lilavati Hospital & Research Centre
Publication Details: The world journal of men's health, Vol.40(3), pp.380-398
Identifiers: 9934742908331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article