Abstract
2-Cyano-
N’
-[1-(2,5-dimethoxyphenyl)]ethylideneacetohydrazide
1
was obtained via reaction of cyanoacetic acid hydrazide with 2,5-dimethoxyacetophenone. A number of novel pyridines
2a–j, 3, 4
, thiophenes
5–9
and thiazoles
10–12
were prepared by using the hydrazide-hydrazone derivative
1
as a starting material. The structure of the newly synthesized compounds was characterized by elemental analyses, IR,
1
H-NMR,
13
C-NMR and mass spectral data. All the target compounds were subjected to
in vitro
antitumor activity against Ehrlich Ascites Carcinoma (EAC) cells. Compounds
2j
and
6
showed a higher activity with IC
50
values (54.54, 61.57 μM), 8 when compared with a reference drug IC
50
value (68.99 μM), while compound
5
is nearly as active as Doxorubicin (CAS 23214-92-8).