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Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines
Journal article   Peer reviewed

Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines

Merla Arjuna Rajendra, Muhammad Naseem, Muthipeedika Nibin Joy, K. Sunil, Ayyiliath Meleveetil Sajith, Fares Howari, Yousef Nazzal, Cijo Xavier, Mohammed B. Alshammari and Karickal Raman Haridas
Molecular diversity, Vol.26(3), pp.1761-1767
01/06/2022
PMID: 34296385

Abstract

Biochemistry & Molecular Biology Chemistry Chemistry, Applied Chemistry, Medicinal Chemistry, Multidisciplinary Life Sciences & Biomedicine Pharmacology & Pharmacy Physical Sciences Science & Technology
We herein report a modified methodology for the synthesis of some oxadiazoles linked to amides under mild conditions. The developed protocol using NMI-TfCl has been found to be effective and tolerant for the amide bond formation reaction of a series of electronically deactivating and sterically challenging amines. The antioxidant potential of the newly synthesized compounds has been evaluated at the later stage. Graphic abstract

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