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Applications of Chemical Ligation in Peptide Synthesis via Acyl Transfer
Journal article   Peer reviewed

Applications of Chemical Ligation in Peptide Synthesis via Acyl Transfer

Siva S Panda, Rachel A Jones, C Dennis Hall and Alan R Katritzky
Topics in current chemistry, Vol.362, pp.229-265
01/01/2015
DOI: https://doi.org/10.1007/128_2014_608
PMID: 25805142

Abstract

Acylation Molecular Structure Peptides - chemical synthesis Peptides - chemistry
The utility of native chemical ligation (NCL) in the solution or solid phase synthesis of peptides, cyclic peptides, glycopeptides, and neoglycoconjugates is reviewed. In addition, the mechanistic details of inter- or intra-molecular NCLs are discussed from experimental and computational points of view.

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