Abstract
In this work, our target point is to focus on rough approximation operators generated from infra-topology spaces and examine their features. First, we show how infra-topology spaces are constructed from N-j-neighborhood systems under an arbitrary relation. Then, we exploit these infra-topology spaces to form new rough set models and scrutinize their master characterizations. The main advantages of these models are to preserve all properties of Pawlak approximation operators and produce accuracy values higher than those given in several methods published in the literature. One of the unique characterizations of the current approach is that all the approximation operators and accuracy measures produced by the current approach are identical under a symmetric relation. Finally, we present two medical applications of the current methods regarding Dengue fever and COVID-19 pandemic. Some debates regarding the pros and cons of the followed technique are given as well as some upcoming work are proposed.