Abstract
Doxorubicin is an effective, potent and commonly used anthracycline-related anticancer drug; however, cardiotoxicity compromises its therapeutic potential. Apremilast, a novel phosphodiesterase type 4-inhibitor, reported to have anti-inflammatory effects and modulating many inflammatory mediators.
The present study investigated the influence of apremilast against doxorubicin-induced cardiotoxicity in male Wistar rats. A total, 24 animals were divided into four groups of six animal each. Group 1, served as control and received normal saline. Group 2 animals, received doxorubicin (20mgkg
, ip). Group 3 and 4, treatment group, received doxorubicin (20mgkg
, ip) with the same schedule as group-2, plus apremilast (10 and 20mgkg
day
, po) respectively. Oxidative stress, caspase-3 enzyme activity, gene expression and protein expression were tested.
The results of the present study demonstrated that administration of apremilast reversed doxorubicin-induced cardiotoxicity.
These findings suggested that apremilast can attenuate doxorubicin-induced cardiotoxicity via inhibition of oxidative stress mediated activation of nuclear factor-kappa B signaling pathways.