Abstract
To assess the association between altitudes of neonatal intensive care units (NICUs) and the incidence of bronchopulmonary dysplasia (BPD) in preterm infants.
Data from infants born at <32 weeks' gestation admitted to NICUs at high altitude (2200 m above sea level) between 2002 and 2011 were analyzed and compared with the data from a lower altitude NICU in Saudi Arabia.
Of 942 preterm infants admitted to the high altitude NICUs, 266 (28.2%) infants developed BPD. The incidence of BPD was significantly higher in infants admitted to the NICU at high altitude than in those at lower altitude (28.2 vs. 17.7%, respectively, p = 0.003). In multivariable analysis, high altitude was significantly associated with a higher risk of BPD (odds ratio: 0.54, 95% confidence interval: 0.36-0.81).
Findings suggest that high altitude may increase the risk of BPD development among preterm infants.