Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study

SANIYA Nissar; TUFAIL AHMAD Lone; MUJEEB ZAFAR Banday; ROOHI Rasool; NISSAR A. Chowdri; FAZL Q. Parray; SAFIYA Abdullah; AGA SYED Sameer; Syed Sameer Aga

doi:10.3892/ol.2013.1104

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Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study

Journal article

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Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study

SANIYA Nissar, TUFAIL AHMAD Lone, MUJEEB ZAFAR Banday, ROOHI Rasool, NISSAR A. Chowdri, FAZL Q. Parray, SAFIYA Abdullah, AGA SYED Sameer and Syed Sameer Aga

Oncology letters, Vol.5(3), pp.959-963

01/03/2013

DOI: https://doi.org/10.3892/ol.2013.1104

PMCID: PMC3576209

PMID: 23426866

Abstract

colorectal cancer

Kashmir

polymorphism

XRCC1

The aim of this study was to investigate the role of the XRCC1 Arg399Gln polymorphism in the susceptibility of a Kashmiri population to colorectal cancer (CRC). We investigated the genotype distribution of the XRCC1 gene in 130 CRC cases in comparison with that of 150 healthy subjects. There was no direct significant association between the XRCC1 genotypes and CRC; however, the Arg/Gln genotype was associated with an elevated risk of CRC (OR>1.47) and the Gln/Gln variant genotype was associated with an increased risk of CRC in various clinicopathological parameters. This study suggests that the XRCC1 polymorphism is associated with an increased risk of CRC.

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Title: Arg399Gln polymorphism of XRCC1 gene and risk of colorectal cancer in Kashmir: A case control study
Creators - without role: SANIYA Nissar - Sher-i-Kashmir Institute of Medical Sciences
TUFAIL AHMAD Lone - Sher-i-Kashmir Institute of Medical Sciences
MUJEEB ZAFAR Banday - University of Kashmir
ROOHI Rasool - University of Kashmir
NISSAR A. Chowdri - Sher-i-Kashmir Institute of Medical Sciences
FAZL Q. Parray - Sher-i-Kashmir Institute of Medical Sciences
SAFIYA Abdullah - University of Kashmir
AGA SYED Sameer - Sher-i-Kashmir Institute of Medical Sciences
Syed Sameer Aga - King Abdulaziz University
Publication Details: Oncology letters, Vol.5(3), pp.959-963
Publisher: D.A. Spandidos
Identifiers: 9920959508331
Academic Unit: King Abdulaziz University; King Saud Bin Abdulaziz University for Health Sciences
Language: English
Resource Type: Journal article