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Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif
Journal article   Peer reviewed

Aryl uracil inhibitors of hepatitis C virus NS5B polymerase: Synthesis and characterization of analogs with a fused 5,6-bicyclic ring motif

A. Chris Krueger, John T. Randolph, David A. DeGoey, Pamela L. Donner, Charles A. Flentge, Douglas K. Hutchinson, Dachun Liu, Christopher E. Motter, Todd W. Rockway, Rolf Wagner, …
Bioorganic & medicinal chemistry letters, Vol.23(12), pp.3487-3490
15/06/2013
DOI: https://doi.org/10.1016/j.bmcl.2013.04.057
PMID: 23664214

Abstract

Aryl uracil Hepatitis C NS5B polymerase inhibitors
The synthesis and structure–activity relationships of a novel aryl uracil series which contains a fused 5,6-bicyclic ring unit for HCV NS5B inhibition is described. Several analogs display replicon cell culture potencies in the low nanomolar range along with excellent rat pharmacokinetic values.

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