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Arylhydrazononitriles as precursors to 2-substituted 1,2,3-triazoles and 4-amino-5-cyano-pyrazole derivatives utilizing microwave and ultrasound irradiation
Journal article   Open access  Peer reviewed

Arylhydrazononitriles as precursors to 2-substituted 1,2,3-triazoles and 4-amino-5-cyano-pyrazole derivatives utilizing microwave and ultrasound irradiation

Khadijah M. Al-Zaydi, Rita M. Borik and Mohamed H. Elnagdi
Green chemistry letters and reviews, Vol.5(3), pp.241-250
09/2012

Abstract

Chemistry Chemistry, Multidisciplinary Green & Sustainable Science & Technology Physical Sciences Science & Technology Science & Technology - Other Topics
Cyanoacetamides 3a-d were prepared by reacting ethyl cyanoacetate with primary aliphatic amines 2a-d. The formed cyanoacetamides 3a-d were coupled with aromatic diazonium salts to give the corresponding arylhydrazones 4a-i which were used as precursors to title triazoles and pyrazoles by reacting with hydroxylamine and chloroacetonitrile. Yields of products formed by conventional heating are compared with those of microwave and ultrasound irradiation
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https://doi.org/10.1080/17518253.2010.483602View
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