Abstract
This study was conducted to assess homocysteine plasma level and insulin resistance profile (blood glucose level, plasma insulin level, HOMA-IR, body mass index) among different groups (non-obese, over-weight and obese) of women with anovulatory infertility. This cross-sectional study was conducted in Suez Canal University hospital in the period from December 2011 to August 2012. Total of 150 women with anovulatory infertility were included in this study, divided equally into three groups: non-obese, over-weight and obese. Blood samples were collected in second or third day of menstrual cycle for laboratory work-up. Hormonal profile and insulin resistance profile were determined for each patient. Plasma level of homocysteine was determined using the commercially available ELISA kit. Results showed that there were statistically significant differences between the three groups regarding homocysteine plasma level, body mass index and HOMA-IR with p-value < 0.001. There was a significant association between homocysteine plasma level and BMI. BMI and serum testosterone level were higher in obese and over-weight women in comparison to non-obese patients. Positive correlations were found between homocysteine plasma level with insulin level, HOMA-IR and LH/FSH ratio. In conclusion, homocysteine plasma level is positively correlated with BMI, insulin resistance, testosterone level and LH/ FSH ratio in over-weight and obese infertile women. This highlights an interaction between high homocysteine level, insulin resistance and hyperandrogenemia, mimicking polycystic ovarian syndrome that could be responsible for the infertile state in these patients. [Nervana MK, Bayoumy, Mohamed M. El-Shabrawi and Khaled A. Atwa. Assessment of Homocysteine Plasma Levels and Insulin Resistance among Obese Women with Anovulatory Infertility. Life Sci J 2012;9(4):1599-1604] (ISSN:1097-8135). http://www.lifesciencesite.com. 244