Abstract
Background: The disadvantage of Edoxaban use is the availability of definitive antidotes with many unfavorable effects. Objectives: This study was planned to determine whether the leaves of Spinacia oleracea ethanol extract can promising the effect of prothrombin complex concentrate (PCC) in the reversal of the anticoagulation development of Edoxaban. Methods: Anesthetized rabbits (n=5) were divided in to following groups, Group I: Normal Saline (negative control); other groups treated with pretreatment of 01 mg/kg Edoxaban followed by Group II: Normal Saline; Group III: 50 IU kg(-1) PCC; Group IV: Spinacia oleracea leaves ethanol extract test doses of 150 mg/kg + 50 IU kg(-1) PCC. After a standardized kidney incision, the volume of blood loss and time to hemostasis was determined. Conclusion: Leaves of Spinacia oleracea may reduce the prothrombin time and blood loss and potentiate the effect of prothrombin complex concentrate in reversing Edoxaban. The additional probe is warranted.