Abstract
Magnetic resonance spectroscopy (MRS) is an effective, safe imaging diagnostic tool which is useful to assess biochemical and metabolic changes in various brain lesions. The study aims to assess different brain lesions using Single Voxel Proton Magnetic Resonance Spectroscopy (MRS). This is a retrospective study conducted at Khartoum State in Sudan from the period of 2017-2019. The participants were examined using MRI and single-voxel proton MRS. The metabolite ratios were assessed and compared to different lesions using independent sample t-test and ANOVA tests. A total of 100 patients (54 males and 46 females; mean age was 43.75 years) were examined. The most prevalent brain lesions were glioblastoma multiforme (GBM) and glioma (24% and 22%). The Cho/Cr ratio was higher in GBM and lymphoma than other brain lesions (4.37 and 4.25 respectively). The NAA/Cr ratio is lower in lymphoma, tuberculoma, inflammation, and abscess (0.6, 1.2, 1.4, and 1.85). The Cho/Cr ratio was significantly higher in neoplastic brain lesions than nonneoplastic one (3.95 vs. 1.74, p-value < 0.001). The nonneoplastic brain lesions had significantly lower peaks of Cho/Cr than neoplastic lesions which have higher peak. GBM and lymphoma have the highest Cho/Cr ratio compared to other brain lesions.