Abstract
Background: Bronchial asthma characterized with inflammation and alteration of immune system activity that induce hyper-reactivity of airways. Inadequate control of associated with impaired sleep quality that adversely influence immunological functions.
Objective: This trial was to measure relation between immune system and sleep parameters among bronchial asthma patients.
Material and Methods: Forty Saudi patients with bronchial asthma consisted of 23 males and 17 females, aged 42-56 year and age matched forty healthy controls consisted of 21 males and 19 females, aged 40-58 year.
Results: The mean value of CD3, CD4, IgG, IgA, IgM, awake time after sleep onset and REM sleep latency were significantly higher in asthma group (A) compared to control group (B). In addition to a significant lower total sleep duration and sleep efficiency in asthma group (A) compared to control group (B). Moreover, CD3, CD4, IgG, IgA, IgM showed a strong inverse relationship with total sleep duration and sleep efficiency and direct relationship with awake time after sleep onset and REM sleep latency in the asthma group (A) (P<0.05).
Conclusion: Immune system response associated with sleep parameters among patients with bronchial asthma.