Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

Tao Huang; Tiange Wang; Yan Zheng; Christina Ellervik; Xiang Li; Meng Gao; Zhe Fang; Jin-Fang Chai; Tarun Veer S Ahluwalia; Yujie Wang; Trudy Voortman; Raymond Noordam; Alexis Frazier-Wood; Markus Scholz; Emily Sonestedt; Masato Akiyama; Rajkumar Dorajoo; Ang Zhou; Tuomas O Kilpeläinen; Marcus E Kleber; Sarah R Crozier; Keith M Godfrey; Rozenn Lemaitre; Janine F Felix; Yuan Shi; Preeti Gupta; Chiea-Chuen Khor; Terho Lehtimäki; Carol A Wang; Carla M T Tiesler; Elisabeth Thiering; Marie Standl; Peter Rzehak; Eirini Marouli; Meian He; Cécile Lecoeur; Dolores Corella; Chao-Qiang Lai; Luis A Moreno; Niina Pitkänen; Colin A Boreham; Tao Zhang; Seang Mei Saw; Paul M Ridker; Mariaelisa Graff; Frank J A van Rooij; Andre G Uitterlinden; Albert Hofman; Diana van Heemst; Frits R Rosendaal; Renée de Mutsert; Ralph Burkhardt; Christina-Alexandra Schulz; Ulrika Ericson; Yoichiro Kamatani; Jian-Min Yuan; Chris Power; Torben Hansen; Thorkild I A Sørensen; Anne Tjønneland; Kim Overvad; Graciela Delgado; Cyrus Cooper; Luc Djousse; Fernando Rivadeneira; Karen Jameson; Wanting Zhao; Jianjun Liu; Nanette R Lee; Olli Raitakari; Mika Kähönen; Jorma Viikari; Veit Grote; Jean-Paul Langhendries; Berthold Koletzko; Joaquin Escribano; Elvira Verduci; George Dedoussis; Caizheng Yu; Yih Chung Tham; Blanche Lim; Sing Hui Lim; Philippe Froguel; Beverley Balkau; Nadia R Fink; Rebecca K Vinding; Astrid Sevelsted; Hans Bisgaard; Oscar Coltell; Jean Dallongeville; Frédéric Gottrand; Katja Pahkala; Harri Niinikoski; Elina Hyppönen; Oluf Pedersen; Winfried März; Hazel Inskip; Vincent W V Jaddoe; Elaine Dennison; Tien Yin Wong; Charumathi Sabanayagam; E-Shyong Tai; Karen L Mohlke; David A Mackey; Dariusz Gruszfeld; Panagiotis Deloukas; Katherine L Tucker; Frédéric Fumeron; Klaus Bønnelykke; Peter Rossing; Ramon Estruch; Jose M Ordovas; Donna K Arnett; Aline Meirhaeghe; Philippe Amouyel; Ching-Yu Cheng; Xueling Sim; Yik Ying Teo; Rob M van Dam; Woon-Puay Koh; Marju Orho-Melander; Markus Loeffler; Michiaki Kubo; Joachim Thiery; Dennis O Mook-Kanamori; Dariush Mozaffarian; Bruce M Psaty; Oscar H Franco; Tangchun Wu; Kari E North; George Davey Smith; Jorge E Chavarro; Daniel I Chasman; Lu Qi; BIRTH-GENE (BIG) Study Working Group

doi:10.1001/jamanetworkopen.2019.10915

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Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

Journal article

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Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study

Tao Huang, Tiange Wang, Yan Zheng, Christina Ellervik, Xiang Li, Meng Gao, Zhe Fang, Jin-Fang Chai, Tarun Veer S Ahluwalia, Yujie Wang, …

JAMA network open, Vol.2(9), pp.e1910915-e1910915

04/09/2019

DOI: https://doi.org/10.1001/jamanetworkopen.2019.10915

PMID: 31539074

Abstract

Adolescent

Adult

Aged

Asian Continental Ancestry Group - genetics

Birth Weight - genetics

Blood Glucose - metabolism

Diabetes Mellitus, Type 2 - epidemiology

Diabetes Mellitus, Type 2 - genetics

European Continental Ancestry Group - genetics

Far East

Female

Genetic Variation

Glycated Hemoglobin A - metabolism

Humans

Infant, Newborn

Insulin - metabolism

Male

Mendelian Randomization Analysis

Middle Aged

Odds Ratio

Polymorphism, Single Nucleotide

Young Adult

Observational studies have shown associations of birth weight with type 2 diabetes (T2D) and glycemic traits, but it remains unclear whether these associations represent causal associations. To test the association of birth weight with T2D and glycemic traits using a mendelian randomization analysis. This mendelian randomization study used a genetic risk score for birth weight that was constructed with 7 genome-wide significant single-nucleotide polymorphisms. The associations of this score with birth weight and T2D were tested in a mendelian randomization analysis using study-level data. The association of birth weight with T2D was tested using both study-level data (7 single-nucleotide polymorphisms were used as an instrumental variable) and summary-level data from the consortia (43 single-nucleotide polymorphisms were used as an instrumental variable). Data from 180 056 participants from 49 studies were included. Type 2 diabetes and glycemic traits. This mendelian randomization analysis included 49 studies with 41 155 patients with T2D and 80 008 control participants from study-level data and 34 840 patients with T2D and 114 981 control participants from summary-level data. Study-level data showed that a 1-SD decrease in birth weight due to the genetic risk score was associated with higher risk of T2D among all participants (odds ratio [OR], 2.10; 95% CI, 1.69-2.61; P = 4.03 × 10-5), among European participants (OR, 1.96; 95% CI, 1.42-2.71; P = .04), and among East Asian participants (OR, 1.39; 95% CI, 1.18-1.62; P = .04). Similar results were observed from summary-level analyses. In addition, each 1-SD lower birth weight was associated with 0.189 SD higher fasting glucose concentration (β = 0.189; SE = 0.060; P = .002), but not with fasting insulin, 2-hour glucose, or hemoglobin A1c concentration. In this study, a genetic predisposition to lower birth weight was associated with increased risk of T2D and higher fasting glucose concentration, suggesting genetic effects on retarded fetal growth and increased diabetes risk that either are independent of each other or operate through alterations of integrated biological mechanisms.

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Title: Association of Birth Weight With Type 2 Diabetes and Glycemic Traits: A Mendelian Randomization Study
Creators - without role: Tao Huang - Peking University
Tiange Wang - University of New Orleans
Yan Zheng - Fudan University
Christina Ellervik - Harvard Medical School
Xiang Li - University of New Orleans
Meng Gao - Peking University
Zhe Fang - Peking University
Jin-Fang Chai - Saw Swee Hock School of Public Health, National University of Singapore, Singapore
Tarun Veer S Ahluwalia - Steno Diabetes Center
Yujie Wang - Department of Epidemiology, University of North Carolina, Chapel Hill
Trudy Voortman - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands
Raymond Noordam - Leiden University Medical Center
Alexis Frazier-Wood - Baylor College of Medicine
Markus Scholz - Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
Emily Sonestedt - Lund University
Masato Akiyama - RIKEN Center for Integrative Medical Sciences
Rajkumar Dorajoo - Genome Institute of Singapore
Ang Zhou - University of South Australia
Tuomas O Kilpeläinen - University of Copenhagen
Marcus E Kleber - University of Mannheim
Sarah R Crozier - University of Southampton
Keith M Godfrey - University Hospital Southampton NHS Foundation Trust
Rozenn Lemaitre - University of Washington
Janine F Felix - Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
Yuan Shi - Singapore Eye Research Institute
Preeti Gupta - Singapore Eye Research Institute
Chiea-Chuen Khor - Genome Institute of Singapore
Terho Lehtimäki - Tampere University
Carol A Wang - Department of Obstetrics and Gynecology, School of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia
Carla M T Tiesler - Helmholtz Zentrum München
Elisabeth Thiering - Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, Klinikum der Universitaet Muenchen, Munich, Germany
Marie Standl - Helmholtz Zentrum München
Peter Rzehak - Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, Klinikum der Universitaet Muenchen, Munich, Germany
Eirini Marouli - Queen Mary University of London
Meian He - MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China
Cécile Lecoeur - Institut Pasteur
Dolores Corella - Instituto de Salud Carlos III
Chao-Qiang Lai - Tufts University
Luis A Moreno - Universidad de Zaragoza
Niina Pitkänen - University of Turku
Colin A Boreham - University College Dublin
Tao Zhang - University of Jinan
Seang Mei Saw - Singapore Eye Research Institute
Paul M Ridker - Brigham and Women's Hospital
Mariaelisa Graff - Department of Epidemiology, University of North Carolina, Chapel Hill
Frank J A van Rooij - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands
Andre G Uitterlinden - Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Albert Hofman - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
Diana van Heemst - Leiden University Medical Center
Frits R Rosendaal - Leiden University Medical Center
Renée de Mutsert - Leiden University Medical Center
Ralph Burkhardt - Institute for Laboratory Medicine, University of Leipzig, Leipzig, Germany
Christina-Alexandra Schulz - Lund University
Ulrika Ericson - Lund University
Yoichiro Kamatani - RIKEN Center for Integrative Medical Sciences
Jian-Min Yuan - University of Pittsburgh
Chris Power - Institute of Child Health
Torben Hansen - University of Copenhagen
Thorkild I A Sørensen - University of Bristol
Anne Tjønneland - Danish Cancer Society
Kim Overvad - Aalborg University Hospital
Graciela Delgado - University of Mannheim
Cyrus Cooper - University of Oxford
Luc Djousse - Brigham and Women's Hospital
Fernando Rivadeneira - Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
Karen Jameson - University of Southampton
Wanting Zhao - Singapore Eye Research Institute
Jianjun Liu - Genome Institute of Singapore
Nanette R Lee - University of San Carlos
Olli Raitakari - Turku University Hospital
Mika Kähönen - Tampere University Hospital
Jorma Viikari - University of Turku
Veit Grote - Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, Klinikum der Universitaet Muenchen, Munich, Germany
Jean-Paul Langhendries - Saint Vincent Health System
Berthold Koletzko - Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, Klinikum der Universitaet Muenchen, Munich, Germany
Joaquin Escribano - Paediatrics Research Unit, Universitat Rovira i Virgili, IISPV, Reus, Spain
Elvira Verduci - University of Milan
George Dedoussis - Harokopio University of Athens
Caizheng Yu - MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China
Yih Chung Tham - Singapore Eye Research Institute
Blanche Lim - Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
Sing Hui Lim - Singapore Eye Research Institute
Philippe Froguel - University of Lille Nord de France
Beverley Balkau - University of Paris-Sud
Nadia R Fink - University of Copenhagen
Rebecca K Vinding - University of Copenhagen
Astrid Sevelsted - University of Copenhagen
Hans Bisgaard - University of Copenhagen
Oscar Coltell - Department of Computer Languages and Systems, University Jaume I, Castellon, Spain
Jean Dallongeville - University of Lille
Frédéric Gottrand - INSERM U995, Hôpital Jeanne de Flandre, CHU-Lille, University of Lille, Lille, France
Katja Pahkala - Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, Turku, Finland
Harri Niinikoski - University of Turku
Elina Hyppönen - South Australian Health and Medical Research Institute, Adelaide, Australia
Oluf Pedersen - University of Copenhagen
Winfried März - Medical University of Graz
Hazel Inskip - University Hospital Southampton NHS Foundation Trust
Vincent W V Jaddoe - Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
Elaine Dennison - Victoria University of Wellington
Tien Yin Wong - Duke-NUS Medical School
Charumathi Sabanayagam - Duke-NUS Medical School
E-Shyong Tai - Duke-NUS Medical School
Karen L Mohlke - Department of Genetics, University of North Carolina, Chapel Hill
David A Mackey - University of Western Australia
Dariusz Gruszfeld - Department of Neonatology and Neonatal Intensive Care, The Children's Memorial Health Institute, Al. Dzieci Polskich 20, Warsaw, Poland
Panagiotis Deloukas - King Abdulaziz University
Katherine L Tucker - University of Massachusetts Lowell
Frédéric Fumeron - Université Paris Cité
Klaus Bønnelykke - University of Copenhagen
Peter Rossing - Steno Diabetes Center
Ramon Estruch - Department of Internal Medicine, Hospital Clinic, IDIBAPS, Barcelona, Spain
Jose M Ordovas - Department of Epidemiology and Population Genetics, Centro Nacional Investigación, Cardiovasculares (CNIC), Madrid, Spain
Donna K Arnett - University of Kentucky
Aline Meirhaeghe - University of Lille
Philippe Amouyel - University of Lille
Ching-Yu Cheng - Duke-NUS Medical School
Xueling Sim - National University of Singapore
Yik Ying Teo - Duke-NUS Medical School
Rob M van Dam - Duke-NUS Medical School
Woon-Puay Koh - Duke-NUS Medical School
Marju Orho-Melander - Lund University
Markus Loeffler - Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
Michiaki Kubo - RIKEN Center for Integrative Medical Sciences
Joachim Thiery - Institute for Laboratory Medicine, University of Leipzig, Leipzig, Germany
Dennis O Mook-Kanamori - Leiden University Medical Center
Dariush Mozaffarian - Tufts University
Bruce M Psaty - Kaiser
Oscar H Franco - Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, Netherlands
Tangchun Wu - MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China
Kari E North - Carolina Center for Genome Sciences, University of North Carolina, Chapel Hill
George Davey Smith - University of Bristol
Jorge E Chavarro - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
Daniel I Chasman - Brigham and Women's Hospital
Lu Qi - University of New Orleans
BIRTH-GENE (BIG) Study Working Group
Publication Details: JAMA network open, Vol.2(9), pp.e1910915-e1910915
Grant note: U01 HL130114 / NHLBI NIH HHS MC_UU_00011/1 / Medical Research Council 19583 / Versus Arthritis MC_UU_12011/4 / Medical Research Council RG/15/17/31749 / British Heart Foundation MC_UP_A620_1017 / Medical Research Council RG/14/5/30893 / British Heart Foundation U01 CA182913 / NCI NIH HHS
Identifiers: 9936588108331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article