Abstract
HLA antigen matching often plays an important role in organ transplantation. As for HLA class I antigen matching, there are differences of opinion regarding its influence on the outcome of renal transplantations. The aim of this study was to evaluate the association of HLA class I antigen matching with early graft outcomes in living donor kidney transplantation.
We evaluated graft outcomes in the first month of transplantation. Major events were slow graft function (serum creatinine > 250 μmol/L at the end of first week), delayed graft function (patients requiring dialysis in first week), and acute rejection episode. Graft outcomes were compared for normal renal function (NRF, serum creatinine ≤ 175 μmol/L) impaired renal function (IRF, serum creatinine > 175 μmol/L) or impaired graft function due to an acute rejection episode (IGF).
The 115 subjects had a mean age of 29 ± 8 years and their donors 38 ± 11 years (
P < .01). Immunosuppression included prednisolone, azathioprine, and cyclosporine. Parents, siblings, and others were kidney donors in 46%, 33%, and 21%, respectively. Comparisons between NRF/IRF (serum creatinine 133 ± 24 vs 201 ± 36 μmol/L,
P < .01) and NGF/IGF (serum creatinine 146 ± 44 vs 161 ± 39 μmol/L,
P < .05) showed no difference in number or pattern of HLA matching.
HLA class I antigen matching may not produce an added influence on early graft outcome among living donor kidney transplantations.