Abstract
The genetic factors as well as microbiological and other environmental factors play a role in the severity and lifetime risk of developing aggressive periodontitis. The aim of this present study was to evaluate the association between interleukin - 1 alpha ((+4845)) gene polymorphisms in Sudanese patients with aggressive periodontitis. We genotyped 30 aggressive periodontitis patients and 32 periodontal health participants for IL-1 alpha ((+4845)) using standard PCR amplification followed by restriction enzyme digestion and gel electrophoresis. Higher prevalence of heterozygous for IL- 1 alpha ((+4845)) was found in localized aggressive patients (64.5%) when compared to controls (35.5%) (P =.005) in this Sudanese population study, while the prevalence of homozygous for IL-1 alpha((+4845)) was higher in control groups (67.7%) than in localized aggressive patients (32.3%) (p=.02).Susceptibility to aggressive periodontitis is increased by heterozygous of IL-1alpha((+4845)). Moreover, IL-1a(+4845) gene polymorphisms is an important risk factor of aggressive periodontitis in Sudanese population.