Association of the 9p21.3 Locus With Risk of First-Ever Myocardial Infarction in Pakistanis Case-Control Study in South Asia and Updated Meta-Analysis of Europeans

Danish Saleheen; Myriam Alexander; Asif Rasheed; David Wormser; Nicole Soranzo; Naomi Hammond; Adam Butterworth; Moazzam Zaidi; Philip Haycock; Suzannah Bumpstead; Simon Potter; Hannah Blackburn; Emma Gray; Emanuele Di Angelantonio; Stephen Kaptoge; Nabi Shah; Maria Samuel; Ahmedyar Janjua; Nasir Sheikh; Shajjia Razi Haider; Muhammed Murtaza; Usman Ahmad; Abdul Hakeem; Muhammad Ali Memon; Nadeem Hayat Mallick; Muhammad Azhar; Abdus Samad; Syed Zahed Rasheed; Ali Raza Gardezi; Nazir Ahmed Memon; Abdul Ghaffar; Fazal-ur-Rehman Memon; Khan Shah Zaman; Assadullah Kundi; Zia Yaqoob; Liaquat Ali Cheema; Nadeem Qamar; Azhar Faruqui; Rashid Jooma; Jawaid Hassan Niazi; Mustafa Hussain; Kishore Kumar; Asim Saleem; Kishwar Kumar; Muhammad Salman Daood; Fatima Memon; Aftab Alam Gul; Shahid Abbas; Junaid Zafar; Faisal Shahid; Zehra Memon; Shahzad Majeed Bhatti; Waleed Kayani; Syed Saadat Ali; Muhammad Fahim; Muhammad Ishaq; Philippe Frossard; Panos Deloukas; John Danesh

doi:10.1161/ATVBAHA.109.197210

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Association of the 9p21.3 Locus With Risk of First-Ever Myocardial Infarction in Pakistanis Case-Control Study in South Asia and Updated Meta-Analysis of Europeans

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Association of the 9p21.3 Locus With Risk of First-Ever Myocardial Infarction in Pakistanis Case-Control Study in South Asia and Updated Meta-Analysis of Europeans

Danish Saleheen, Myriam Alexander, Asif Rasheed, David Wormser, Nicole Soranzo, Naomi Hammond, Adam Butterworth, Moazzam Zaidi, Philip Haycock, Suzannah Bumpstead, …

Arteriosclerosis, thrombosis, and vascular biology, Vol.30(7), pp.1467-U498

07/2010

DOI: https://doi.org/10.1161/ATVBAHA.109.197210

PMID: 20395598

Abstract

Cardiovascular System & Cardiology

Hematology

Life Sciences & Biomedicine

Peripheral Vascular Disease

Science & Technology

Objective-To examine variants at the 9p21 locus in a case-control study of acute myocardial infarction (MI) in Pakistanis and to perform an updated meta-analysis of published studies in people of European ancestry. Methods and Results-A total of 1851 patients with first-ever confirmed MI and 1903 controls were genotyped for 89 tagging single-nucleotide polymorphisms at locus 9p21, including the lead variant (rs1333049) identified by the Wellcome Trust Case Control Consortium. Minor allele frequencies and extent of linkage disequilibrium observed in Pakistanis were broadly similar to those seen in Europeans. In the Pakistani study, 6 variants were associated with MI (P<10(-2)) in the initial sample set, and in an additional 741 cases and 674 controls in whom further genotyping was performed for these variants. For Pakistanis, the odds ratio for MI was 1.13 (95% CI, 1.05 to 1.22; P=2 x 10(-3)) for each copy of the C allele at rs1333049. In comparison, a meta-analysis of studies in Europeans yielded an odds ratio of 1.31 (95% CI, 1.26 to 1.37) for the same variant (P=1 x 10(-3) for heterogeneity). Meta-analyses of 23 variants, in up to 38 250 cases and 84 820 controls generally yielded higher values in Europeans than in Pakistanis. Conclusion-To our knowledge, this study provides the first demonstration that variants at the 9p21 locus are significantly associated with MI risk in Pakistanis. However, association signals at this locus were weaker in Pakistanis than those in European studies. (Arterioscler Thromb Vasc Biol. 2010; 30: 1467-1473.)

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Title: Association of the 9p21.3 Locus With Risk of First-Ever Myocardial Infarction in Pakistanis Case-Control Study in South Asia and Updated Meta-Analysis of Europeans
Creators - without role: Danish Saleheen - Ctr Noncommunicable Dis, Karachi, Pakistan
Myriam Alexander - University of Cambridge
Asif Rasheed - Ctr Noncommunicable Dis, Karachi, Pakistan
David Wormser - University of Cambridge
Nicole Soranzo - Wellcome Sanger Institute
Naomi Hammond - Wellcome Sanger Institute
Adam Butterworth - University of Cambridge
Moazzam Zaidi - Ctr Noncommunicable Dis, Karachi, Pakistan
Philip Haycock - University of Cambridge
Suzannah Bumpstead - Wellcome Sanger Institute
Simon Potter - Wellcome Sanger Institute
Hannah Blackburn - Wellcome Sanger Institute
Emma Gray - Wellcome Sanger Institute
Emanuele Di Angelantonio - University of Cambridge
Stephen Kaptoge - University of Cambridge
Nabi Shah - Ctr Noncommunicable Dis, Karachi, Pakistan
Maria Samuel - Ctr Noncommunicable Dis, Karachi, Pakistan
Ahmedyar Janjua - Ctr Noncommunicable Dis, Karachi, Pakistan
Nasir Sheikh - University of Cambridge
Shajjia Razi Haider - Ctr Noncommunicable Dis, Karachi, Pakistan
Muhammed Murtaza - Ctr Noncommunicable Dis, Karachi, Pakistan
Usman Ahmad - Ctr Noncommunicable Dis, Karachi, Pakistan
Abdul Hakeem - Ctr Noncommunicable Dis, Karachi, Pakistan
Muhammad Ali Memon - Ctr Noncommunicable Dis, Karachi, Pakistan
Nadeem Hayat Mallick - Punjab Inst Cardiol, Lahore, Pakistan
Muhammad Azhar - Punjab Inst Cardiol, Lahore, Pakistan
Abdus Samad
Syed Zahed Rasheed - Karachi Inst Heart Dis, Karachi, Pakistan
Ali Raza Gardezi - Chaudhury Perwaiz Elahi Inst Cardiol, Multan, Pakistan
Nazir Ahmed Memon - College Station Medical Center
Abdul Ghaffar - College Station Medical Center
Fazal-ur-Rehman Memon - Red Crescent Inst Cardiol, Hyderabad, Andhra Pradesh, India
Khan Shah Zaman - Natl Inst Cardiovasc Dis, Karachi, Pakistan
Assadullah Kundi - Natl Inst Cardiovasc Dis, Karachi, Pakistan
Zia Yaqoob - Natl Inst Cardiovasc Dis, Karachi, Pakistan
Liaquat Ali Cheema - Natl Inst Cardiovasc Dis, Karachi, Pakistan
Nadeem Qamar - Natl Inst Cardiovasc Dis, Karachi, Pakistan
Azhar Faruqui - Natl Inst Cardiovasc Dis, Karachi, Pakistan
Rashid Jooma - College Station Medical Center
Jawaid Hassan Niazi - College Station Medical Center
Mustafa Hussain - Ctr Noncommunicable Dis, Karachi, Pakistan
Kishore Kumar - Ctr Noncommunicable Dis, Karachi, Pakistan
Asim Saleem - Ctr Noncommunicable Dis, Karachi, Pakistan
Kishwar Kumar - Ctr Noncommunicable Dis, Karachi, Pakistan
Muhammad Salman Daood - Ctr Noncommunicable Dis, Karachi, Pakistan
Fatima Memon - Ctr Noncommunicable Dis, Karachi, Pakistan
Aftab Alam Gul - Ctr Noncommunicable Dis, Karachi, Pakistan
Shahid Abbas - Ctr Noncommunicable Dis, Karachi, Pakistan
Junaid Zafar - Ctr Noncommunicable Dis, Karachi, Pakistan
Faisal Shahid - Ctr Noncommunicable Dis, Karachi, Pakistan
Zehra Memon - Ctr Noncommunicable Dis, Karachi, Pakistan
Shahzad Majeed Bhatti - Ctr Noncommunicable Dis, Karachi, Pakistan
Waleed Kayani - Ctr Noncommunicable Dis, Karachi, Pakistan
Syed Saadat Ali - Ctr Noncommunicable Dis, Karachi, Pakistan
Muhammad Fahim - Ctr Noncommunicable Dis, Karachi, Pakistan
Muhammad Ishaq - Karachi Inst Heart Dis, Karachi, Pakistan
Philippe Frossard - Ctr Noncommunicable Dis, Karachi, Pakistan
Panos Deloukas - Wellcome Sanger Institute
John Danesh - University of Cambridge
Publication Details: Arteriosclerosis, thrombosis, and vascular biology, Vol.30(7), pp.1467-U498
Publisher: Lippincott Williams & Wilkins
Number of pages: 30
Grant note: Wellcome Trust; European Commission UK Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC) University of Cambridge British Heart Foundation RG/08/014/24067 / British Heart Foundation Yousef Jameel Foundation; American University Cairo Marie Curie Bloodomics scholarship
Identifiers: 9935599908331
Academic Unit: King Abdulaziz University
Language: English
Resource Type: Journal article