Asymmetric synthesis of anticancer beta-lactams via Staudinger reaction: Utilization of chiral ketene from carbohydrate

Bimal K. Banik; Indrani Banik; Frederick F. Becker

doi:10.1016/j.ejmech.2009.11.024

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Asymmetric synthesis of anticancer beta-lactams via Staudinger reaction: Utilization of chiral ketene from carbohydrate

Journal article

Peer reviewed

Asymmetric synthesis of anticancer beta-lactams via Staudinger reaction: Utilization of chiral ketene from carbohydrate

Bimal K. Banik, Indrani Banik and Frederick F. Becker

European journal of medicinal chemistry, Vol.45(2), pp.846-848

01/02/2010

DOI: https://doi.org/10.1016/j.ejmech.2009.11.024

PMID: 19962794

Abstract

Chemistry, Medicinal

Life Sciences & Biomedicine

Pharmacology & Pharmacy

Science & Technology

We describe herein asymmetric synthesis of a novel anticancer beta-lactam following Staudinger reaction with chiral carbohydrate as the ketene component with an achiral imine. The in vitro cytotoxicity studies of these beta-lactams are also reported here. (C) 2009 Published by Elsevier Masson SAS.

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Title: Asymmetric synthesis of anticancer beta-lactams via Staudinger reaction: Utilization of chiral ketene from carbohydrate
Creators - without role: Bimal K. Banik - Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX, 78539, USA.
Indrani Banik - The University of Texas MD Anderson Cancer Center
Frederick F. Becker - The University of Texas MD Anderson Cancer Center
Publication Details: European journal of medicinal chemistry, Vol.45(2), pp.846-848
Publisher: Elsevier
Number of pages: 3
Grant note: Cha Family Fund 2S06M008038-37 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
Identifiers: 9924861308331
Academic Unit: Prince Mohammad Bin Fahd University
Language: English
Resource Type: Journal article